Nano Particle Analyzer
HORIBA LB-550V
"the sample" (1)
the sample - Particle Measurement
In this special issue of “the sample” we present the entire product range of particle analyzers on offer from Retsch Technology.
Test Reports (5)
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Critical Micelle Concentration Determination
Surfactants may self-assemble into structures called micelles when they reach a concentration known as the critical micelle concentration (CMC). While individual surfactant molecules are too small for detection by most sizing techniques micelles are large enough for particle size analysis using the dynamic light scattering (DLS) technique. It is important to understand where the CMC is for many systems because of the interplay between micelles and lipophilic proteins. Additionally, locating the CMC is necessary when using surfactants to disperse powders as the formation of micelles is followed by particle agglomeration/aggregation. This study describes an experiment to determine the CMC of Triton X-100 using a DLS-based particle size analyzer.
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Inks
Inks are dispersions of pigments used to impart color to a substrate. There are a huge variety of applications, including writing pens, printing inks for magazines and books, inkjet printers for computers, and packaging materials including paper-based materials and plastics. This leads to an equally wide range of inks, each optimized for the particular application.
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Liposomes
Rapid and accurate measurement of liposome size is important for the development of drug delivery systems in the pharmaceutical industry. The HORIBA LB-550 is perfectly suited for liposome size measurement because very little liposome quantity is needed (about 700 ul sample at 0.01 mg/ml), and the sample can be recovered easily.
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Particle size analysis of gold nanoparticles
Scientific interest in well dispersed suspensions of colloidal gold (or nanoparticles) can be traced back to ancient times. Original uses of colloidal gold included potions, stained glass, and other artistic expressions. Current research using gold dispersions remains quite active and controlling the size and morphology of the particles is critical. Recently, the National Institute of Standards and Technology (NIST) has developed Reference Materials (RMs) of gold nanoparticles that are nominally 10, 30, and 60 nm. This application note describes a procedure and shows results.
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Protein Aggregation
The study of protein aggregation encompasses a broad range of interactions and mechanisms. Many studies into this subject area investigate the aggregation of misfolded proteins, which is thought to be responsible for many degenerative diseases. Since aggregation typically leads to a physical change in protein size, particle size analysis has proven to be a useful ex-perimental technique in this field. Dynamic light scat-tering (DLS) is now widely used to study protein ag-gregation as described in this application note.
Subject to technical modifications and errors
